PTC Therapeutics, Inc. (PTC) data suggests that the quantification of cough frequency may offer a clinically meaningful outcome measure in CF. According to data, patients with CF cough 324 to 1,569 times per day, with an average of 643 coughs per day, while healthy individuals generally cough fewer than 16 times in an entire day.
“Frequent and intense coughing has a profound effect on the overall quality of life of the patient – compromising work, school, sleep and social interactions.” stated Eitan Kerem, M.D., head of the Department of Pediatrics and Cystic Fibrosis Center, Hadassah University Hospital.
The study was designed to assess cough frequency as a measure of clinical benefit. Quantitative measurement was achieved using a new technology which integrates cough signals from chest wall motion transducers and a throat microphone and stores the data for computer analysis. Patients included 19 adults not in CF exacerbation, compliance was excellent, with cough data collected for a median of 24 hours.